Protein name:
Oncostatin-M-specific receptor subunit beta ;
Alternative:
Interleukin-31 receptor subunit beta (IL-31 receptor subunit beta;IL-31R subunit beta;IL-31R-beta;IL-31RB) ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Heterodimer composed of OSMR and IL6ST (type II OSM receptor). Heterodimer with IL31RA to form the IL31 receptor.
Function:
Associates with IL31RA to form the IL31 receptor. Binds IL31 and activates STAT1, STAT3 and STAT5. Capable of transducing OSM-specific signaling events (By similarity). The OSM/OSM-R system is pivotal in the differentiation of oval cells into hepatocytes, thereby promoting liver regeneration.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MAFSVVLHQV | TFLLAVLSLR | TSQSKVLGEP | LQLTPEIHTV | SLQSALQEAN |
100:
LEWTVPTFSH | QELNIVFQIE | ISRMRTSNTI | WVGNYSTTVK | HEETVHWKWT |
150:
SDIPLECATH | FIRIRAMVDD | AQYPPQSSWS | NWSSWKEVNA | QVSVPPDTLL |
200:
IFPEDRLLEE | GSNVTICLMI | GQNLYNVSCK | LQEEPIRGEQ | LDSHLSLIKL |
250:
NNVVFLNNAG | TNINCKAMNG | TKNTFGTVLF | VSKVLEEPKN | FSCETRDFKT |
300:
LNCLWEPGID | TTLSWHKQRS | QHYTLYESFS | GRREVSNHRN | SHTWQITEDS |
350:
QETYNFTLTA | ENNLRKRSVS | ISFNLTHRVH | PKAPHDVTLK | TVGATKAHMT |
400:
WKVPSRGDYT | LLCQVELQCE | GEVIHEHNVS | VHTSANYLFS | DLEPDTEYKA |
450:
CVRCASANHF | WKWSDWMQKK | FRTPEAAPSE | ALDVWRDVRT | ENGRHVVTLF |
500:
WKPLLKSQAN | GKIISYNIVV | ENEANPTESE | QYSVRAPALG | TNLSLDLHPY |
550:
KIHISANNSA | GASPESLVVL | SSHSGHEEVH | EKTIKGIKNG | FNISWEPVSG |
600:
DAIGYVVDWC | AHSQTQRCDL | QWKNVGPNIT | STIITSDAFE | PGVRYNFRIF |
650:
ERSVEENVRL | VEKQRGYTQE | LAPSVNPGVT | IHNLTPNSFS | LKWQDYASDF |
700:
QSGFIKGYLV | YLKSKELQCN | PNWERTVLSD | KSVLCKYDVD | DPETKTLTVE |
750:
NLRPESLYEF | LVTPYTSAGQ | GPNETYTKVT | TPDVRSHMLL | QIILPMTLGV |
800:
FLSIIVCYWK | SQWVKEKCYP | DIPNPYKSSI | LSLIKSKKNP | HLIMNVKDCI |
850:
PDVLEVINKA | EGSKTQCVGS | GKLHTEDVPT | KPPLVPTEKD | SSGPMPFVFL |
900:
ENFTYDQSAF | DSGSHGFIPG | PLKNTPHQLG | LLAPPNKLQN | VLENDYMKSL |
950:
VESPTEETSL | IYVSQLASPI | CGDKDSLVTN | PPMPVHGSEY | KKQMALPGSL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Rat Oncostatin-M-specific receptor subunit beta
ELISA Kit for Rat Oncostatin-M-specific receptor subunit beta
ELISA Kit for Rat Oncostatin-M-specific receptor subunit beta
CLIA Kit for Rat Oncostatin-M-specific receptor subunit beta
CLIA Kit for Rat Oncostatin-M-specific receptor subunit beta
CLIA Kit for Rat Oncostatin-M-specific receptor subunit beta
Polyclonal Antibody for Rat Oncostatin-M-specific receptor subunit beta
Polyclonal Antibody for Rat Oncostatin-M-specific receptor subunit beta
Polyclonal Antibody for Rat Oncostatin-M-specific receptor subunit beta
Monoclonal Antibody for Rat Oncostatin-M-specific receptor subunit beta
Monoclonal Antibody for Rat Oncostatin-M-specific receptor subunit beta
Monoclonal Antibody for Rat Oncostatin-M-specific receptor subunit beta
Protein for Rat Oncostatin-M-specific receptor subunit beta
Protein for Rat Oncostatin-M-specific receptor subunit beta
Protein for Rat Oncostatin-M-specific receptor subunit beta
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Oncostatin M inhibits proliferation of rat oval cells, OC15-5, inducing differentiation into hepatocytes."
Okaya A.
,
Kitanaka J.
,
Kitanaka N.
,
Satake M.
,
Kim Y.
,
Terada K.
,
Sugiyama T.
,
Takemura M.
,
Fujimoto J.
,
Terada N.
,
Miyajima A.
,
Tsujimura T.
Am. J. Pathol.166:709-719(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY